Content
| Sr. No. | Content |
| 1 | Introduction to phytosome |
| 2 | Preparation of Phytosome |
| 3 | Properties of phytosomes |
| 4 | PHYTOSOME A Technical revolution in phytomedicine |
| 5 | The Flavonoids |
| 6 | Green Tea Phytosome |
| 7 | LEUCO PHYTOSOME |
| 8 | Hawthron Phytosome |
| 9 | Grape Seed Phytosome: |
| 10 | Conclusion |
| 11 | References |
Introduction to phytosome
Introduction
A large number of herbal drugs possess the wide spectrum of therapeutic activity. But the potential use of these herbal drugs is limited due to their poor absorption and poor bioavailability after oral administration. The bioavailability can be improved by the use of delivery systems, which can enhance the rate and the extent of drug solubilizing into aqueous intestinal fluids as well as the capacity to cross the lipid rich biomembranes. Phospholipid based drug delivery systems have been found promising for the effective and efficacious herbal drug delivery. Complexing the polyphenolic phytoconstituents in molar ratio with phosphatidylcholine results into a new herbal drug delivery system- "Phytosome". Phytosomes show better pharmacokinetic and therapeutic profile than conventional herbal extracts. It having large application in hepatoprotective and antihepatotoxic activity.
The term “phyto” means plant while “some” means cell like.
The Phytosome process produces is a little cell whereby the valuable components of the herbal extract are protected from destruction by digestive secretions and gut bacteria.
Most of the bioactive constituents of herbal drugs are water soluble molecules However, water soluble phytoconstituents like many flavonoids are poorly absorbed(1) either due to their multiple-ring large size molecules which can not be absorbed by simple diffusion, or due to their poor miscibility with oils and other lipids, severely limiting their ability to pass across the lipid-rich outer membranes of the enterocytes of the small intestine.
Water-soluble phytoconstituent molecules (mainly polyphenoles) can be converted into lipid-compatible molecular complexes, which are called phytosomes.
Phytosomes are more bioavailable as compared to simple herbal extracts owing to their enhanced capacity to cross the lipid rich biomembranes and finally reaching the blood(2). The lipid-phase substances employed to make phytoconstituents, lipid-compatible are phospholipids from soy, mainly phosphatidylcholine (PC).
Phospholipids are complex molecules that are used in all known life forms to make cell membranes. They are cell membrane building blocks, making up the matrix into which fit a large variety of proteins that are enzymes, transport proteins, receptors, and other biological energy converters.
They are miscible both in water and in oil/ lipid environments, and are well absorbed orally. Phospholipids are small lipid molecules in which the glycerol is bonded only to two fatty acids, instead of three as in triglycerides, with the remaining site occupied by a
Impressum
Verlag: BookRix GmbH & Co. KG
Tag der Veröffentlichung: 17.12.2015
ISBN: 978-3-7396-2848-6
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